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Each vial ships with structural data and lot identifiers for the compound, plus a Certificate of Analysis documenting purity and identity. Ready for the bench. Synthesized via solid-phase peptide synthesis (SPPS), purified by reverse-phase HPLC, verified by mass spectrometry, and tested for sterility and endotoxin load. Every spec is documented on the signed Certificate of Analysis that ships with your vial.
MOTS-c (Mitochondrial Open Reading frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded by the mitochondrial genome itself rather than the nuclear genome. It is one of the first identified members of the mitochondrial-derived peptide (MDP) family.
In published preclinical literature, MOTS-c has been investigated for its role in cellular energy metabolism via the AMPK pathway, with studies examining glucose uptake, insulin sensitivity, and metabolic homeostasis in rodent models. Plasma MOTS-c concentrations have been documented to decline with age in human studies, which has driven academic interest in its biology.
The peptide is most-cited alongside investigations of AMPK activation, mitochondrial bioenergetics, exercise physiology, and obesity / insulin-resistance models. It has not been approved by the FDA for any therapeutic indication and remains classified as a research compound.
Lee C, et al. (2015) · Cell Metab
MOTS-c: A Mitochondrial-Derived Peptide Regulating Muscle and Fat Metabolism
PubMed · PubMed · 25738463Reynolds JC, et al. (2021) · Nat Commun
MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis
PubMed · PubMed · 3394176210mg / single compound
10mg / single compound
10mg / single compound
MOTS-c is one of the first identified mitochondrial-derived peptides (MDPs) — peptides encoded by the mitochondrial genome rather than by nuclear DNA. The 16-amino-acid sequence (MRWQEMGYIFYPRKLR) is read from the 12S rRNA region of the mitochondrial DNA and translated within the mitochondrion itself. Most other research peptides are nuclear-encoded; MDPs are a relatively new class with distinct biology. This is part of why MOTS-c is studied separately from other GH-axis or tissue-repair peptides — it sits in a different signaling family.
Mitochondrial Open reading frame of the Twelve S rRNA, type c. The name describes where the peptide-encoding sequence sits in the mitochondrial genome. It was first characterized by the Cohen lab (USC) in 2015.
Every lot is tested by reverse-phase HPLC and certified at ≥99% purity. The Certificate of Analysis lists the exact lot purity (most lots run between 99.5% and 99.9%). Your COA ships with the vial and is also retrievable by lot number through our online verifier.
Testing is done by BioRegen Analytical, an independent third-party lab. Every batch goes through HPLC purity, LC-MS identity confirmation, sterility screening, and LAL endotoxin testing. The signed Certificate of Analysis ships with each vial. Same lot number, same COA, every time.
Made in the USA. Synthesized in a US cGMP-aligned facility. Tested by a US-based independent lab. Shipped from US fulfillment.
Orders ship via 2-day expedited delivery from US fulfillment. Free over $150. Vials are sealed, packaged with insulation, and shipped in tamper-evident packaging. Tracking number is sent the same day your order leaves the warehouse.
30-day money-back guarantee on every order. If a vial arrives damaged, fails to match the COA, or you change your mind within 30 days, contact us and we will refund or replace. No restocking fees, no return shipping cost on defective product.
One sealed 10mg vial of MOTS-c as a white powder. Lot-stamped label. Signed Certificate of Analysis. Tamper-evident packaging. Bacteriostatic water for reconstitution research is sold separately and can be added in the cart.
30-day money back · Free shipping over $150 · 2-day shipping
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