Lot #260618MO103

Price range: $40.00 through $102.00
Price range: $40.00 through $80.00

Mitochondria-Derived Peptide (MOTS-c)

MOTS-C [10mg]

10mg / vial

Mitochondria-derived peptide

≥99% HPLC

4.9 / 5

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Price range: $40.00 through $102.00
Price range: $40.00 through $80.00

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≥99% HPLC Purity

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Compound Profile

Researcher-grade specs. No guesswork.

Each vial ships with structural data and lot identifiers for the compound, plus a Certificate of Analysis documenting purity and identity. Ready for the bench. Synthesized via solid-phase peptide synthesis (SPPS), purified by reverse-phase HPLC, verified by mass spectrometry, and tested for sterility and endotoxin load. Every spec is documented on the signed Certificate of Analysis that ships with your vial.

— Component 01
MOTS-c · 10mg
Class
Mitochondria-derived peptide (MDP) / Mitochondrial ORF of 12S rRNA-c
Sequence
Met-Arg-Trp-Gln-Glu-Met-Gly-Tyr-Ile-Phe-Tyr-Pro-Arg-Lys-Leu-Ala (16 aa)
CAS Number
1457222-14-8
Molecular Formula
C₁₀₁H₁₅₂N₂₈O₂₂S₂
Molecular Weight
2,174.6 g/mol
Per-component purity
≥ 99%
In the Literature

One compound. One research record.

MOTS-c (Mitochondrial Open Reading frame of the 12S rRNA-c) is a 16-amino-acid peptide encoded by the mitochondrial genome itself rather than the nuclear genome. It is one of the first identified members of the mitochondrial-derived peptide (MDP) family.

In published preclinical literature, MOTS-c has been investigated for its role in cellular energy metabolism via the AMPK pathway, with studies examining glucose uptake, insulin sensitivity, and metabolic homeostasis in rodent models. Plasma MOTS-c concentrations have been documented to decline with age in human studies, which has driven academic interest in its biology.

The peptide is most-cited alongside investigations of AMPK activation, mitochondrial bioenergetics, exercise physiology, and obesity / insulin-resistance models. It has not been approved by the FDA for any therapeutic indication and remains classified as a research compound.

For research use only. Statements above describe published research literature and do not constitute health, medical, or therapeutic claims for either compound or for the blend. Not for human or veterinary use. Not evaluated by the FDA.

Documented Research Areas

  • AMPK pathway activation and cellular energy sensing
  • Glucose uptake and insulin sensitivity (rodent models)
  • Mitochondrial bioenergetics and oxidative phosphorylation
  • High-fat-diet-induced obesity and metabolic homeostasis
  • Exercise physiology and skeletal muscle research
  • Aging biology and plasma MOTS-c decline studies

Selected Studies · Peer-Reviewed Literature

A curated list of published peer-reviewed papers indexed in PubMed where BPC-157 has been studied. Provided for research-context only. Linking to the literature does not constitute endorsement of any therapeutic application.

01

Lee C, et al. (2015) · Cell Metab

MOTS-c: A Mitochondrial-Derived Peptide Regulating Muscle and Fat Metabolism

PubMed · PubMed · 25738463
02

Reynolds JC, et al. (2021) · Nat Commun

MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis

PubMed · PubMed · 33941762

Compound database reference for chemical and structural data:

Transparency

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Each batch ships with a third-party Certificate of Analysis from BioRegen Analytical. HPLC purity, mass-spectrometry identity, sterility, and LAL endotoxin screening. Every test, every lot.

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Certificate of Analysis

CompoundMOTS-C
CAS#1457222-14-8
FormulaC₁₀₁H₁₅₂N₂₈O₂₂S₂
Mol. Weight2,174.6 g/mol
Identity (LC-MS)PASS
Purity (HPLC)99.76%
Sterility / LALPASS
Date Tested17 Jul 2026

Pairs With

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Common Questions

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